Essential roles of HDAC1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development

Essential roles of HDAC1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development

Epigenetic modifications, including DNA methylation and histone modifications, are reprogrammed considerably following fertilization during mammalian early embryonic development. Incomplete epigenetic reprogramming is a major factor leading to poor developmental outcome in embryos generated by assis...

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Bibliographic Details
Main Authors: Panpan Zhao, Huanan Wang, Han Wang, Yanna Dang, Lei Luo, Shuang Li, Yan Shi, Lefeng Wang, Shaohua Wang, Jesse Mager, Kun Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2020-04-01
Series:Epigenetics
Subjects:
preimplantation
hdac1
hdac2
trophectoderm
pluripotency
dna methylation
Online Access:http://dx.doi.org/10.1080/15592294.2019.1669375

Internet

http://dx.doi.org/10.1080/15592294.2019.1669375

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