Tribbles-1 Expression and Its Function to Control Inflammatory Cytokines, Including Interleukin-8 Levels are Regulated by miRNAs in Macrophages and Prostate Cancer Cells

Tribbles-1 Expression and Its Function to Control Inflammatory Cytokines, Including Interleukin-8 Levels are Regulated by miRNAs in Macrophages and Prostate Cancer Cells

The pseudokinase TRIB1 controls cell function in a range of contexts, by regulating MAP kinase activation and mediating protein degradation via the COP1 ubiquitin ligase. TRIB1 regulates polarization of macrophages and dysregulated Trib1 expression in murine models has been shown to alter atheroscle...

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Bibliographic Details
Main Authors: Chiara Niespolo, Jessica M. Johnston, Sumeet R. Deshmukh, Swapna Satam, Ziyanda Shologu, Oscar Villacanas, Ian M. Sudbery, Heather L. Wilson, Endre Kiss-Toth
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
miRNA
Tribbles
macrophages
prostate cancer
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.574046/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.574046/full

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