Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in yeast

Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in yeast

A quantitative trait locus (QTL) in the nematode C. elegans, lsq4, was recently implicated by mapping longevity genes. QTLs for lifespan and 3 stress-resistance traits coincided within a span of <300 kbp, later narrowed to <200 kbp. A single gene in this interval is now shown to modulate all...

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Bibliographic Details
Main Authors: Srinivas eAyyadevara, Cagdas eTazearslan, Ramani eAlla, James C Jiang, S Michal Jazwinski, Robert Joseph Shmookler Reis
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Genetics
Subjects:
Oxidative Stress
heat shock
Lifespan
natural selection
genetics of aging
RNA interference (RNAi)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00211/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00211/full

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