Amino Acid Biosynthesis Regulation during Endoplasmic Reticulum Stress Is Coupled to Protein Expression Demands

Summary: The endoplasmic reticulum (ER) stress response, also known as the unfolded protein response (UPR), is a complex cellular response to ER protein misfolding that involves transcriptional regulatory branches and a PERK-mediated translational regulatory branch.Here we revealed that amino acid b...

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Bibliographic Details
Main Authors: Nir Gonen, Anatoly Meller, Niv Sabath, Reut Shalgi
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219302470