Metabolism and disposition of oseltamivir (OS) in rats, determined by immunohistochemistry with monospecific antibody for OS or its active metabolite oseltamivir carboxylate (OC): A possibility of transporters dividing the drugs’ excretion into the bile and kidney
Abstract Among any drugs, no comparative pharmacological study on how prodrug and its active metabolite behave in animal bodies is available. Immunohistochemistry (IHCs) using newly prepared two monoclonal antibodies, AOS‐96 and AOC‐160, monospecific for oseltamivir (OS) and its metabolite oseltamiv...
| Main Authors: | , , , |
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| Format: | Article |
| Jezik: | English |
| Izdano: |
Wiley
2020-06-01
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| Serija: | Pharmacology Research & Perspectives |
| Teme: | |
| Online dostop: | https://doi.org/10.1002/prp2.597 |