A novel multi-component protein vaccine ECP001 containing a protein polypeptide antigen nPstS1 riching in T-cell epitopes showed good immunogenicity and protection in mice

A novel multi-component protein vaccine ECP001 containing a protein polypeptide antigen nPstS1 riching in T-cell epitopes showed good immunogenicity and protection in mice

Tuberculosis (TB) is an infectious disease that seriously affects human health. Until now, the only anti-TB vaccine approved for use is the live attenuated Mycobacterium bovis (M. bovis) vaccine — BCG vaccine, but its protective efficacy is relatively low and does not provide satisfactory protection...

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Bibliographic Details
Main Authors: Jinjie Yu, Xueting Fan, Xiuli Luan, Ruihuan Wang, Bin Cao, Chengyu Qian, Guilian Li, Machao Li, Xiuqin Zhao, Haican Liu, Kanglin Wan, Xiuqin Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
mycobacterium tuberculosis
ESAT-6
CFP-10
nPstS1
adjuvant
recombinant subunit protein vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1138818/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1138818/full

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