Epidermal–dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures

Abstract Tissue patterning is critical for the development and regeneration of organs. To advance the use of engineered reconstituted skin organs, we study cardinal features important for tissue patterning and hair regeneration. We find they spontaneously form spheroid configurations, with polarized...

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Bibliographic Details
Main Authors: Mingxing Lei, Jingwei Jiang, Mengyue Wang, Wang Wu, Jinwei Zhang, Wanqian Liu, Wei Zhou, Yung-Chih Lai, Ting-Xin Jiang, Randall B. Widelitz, Hans I-Chen Harn, Li Yang, Cheng-Ming Chuong
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-023-00340-0