Chia (Salvia hispanica L.) oil supplementation ameliorates liver oxidative stress in high-fat diet-fed mice through PPAR-γ and Nrf2 upregulation
This study aimed to evaluate the hepatic antioxidant activity of a high-fat diet supplemented with chia oil in mice. Forty animals were divided into Control (C, n = 10), Control + 1.5 % chia oil (CC, n = 10), High fat (HF, n = 10), and High fat + 1.5 % chia oil (HFC, n = 10) groups. Chia oil reduced...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623000622 |
| _version_ | 1827994076153118720 |
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| author | Aline Batista Fernanda Torres Quitete Thamara Cherem Peixoto André Almo Elisa Bernardes Monteiro Patrícia Trindade Lilia Zago Marta Citelli Julio Beltrame Daleprane |
| author_facet | Aline Batista Fernanda Torres Quitete Thamara Cherem Peixoto André Almo Elisa Bernardes Monteiro Patrícia Trindade Lilia Zago Marta Citelli Julio Beltrame Daleprane |
| author_sort | Aline Batista |
| collection | DOAJ |
| description | This study aimed to evaluate the hepatic antioxidant activity of a high-fat diet supplemented with chia oil in mice. Forty animals were divided into Control (C, n = 10), Control + 1.5 % chia oil (CC, n = 10), High fat (HF, n = 10), and High fat + 1.5 % chia oil (HFC, n = 10) groups. Chia oil reduced serum triacylglycerol in the HF group (p < 0.05). Chia oil promotes lower hepatic concentrations of F2-isoprostane (8-epi PGF2α) and thiobarbituric acid (TBARs) than HF. Chia oil increased liver protein expression and activity of superoxide dismutase 1 and 2 (SOD1 and SOD2), catalase (CAT), and glutathione peroxidase (GPx). It also upregulated the expression of PPAR-γ and NRF2, a master transcription factor involved in the antioxidant response in the liver, compared to their counterparts. The results reveal that chia oil improves the metabolic and antioxidant systems in the liver of high-fat diet-fed mice. |
| first_indexed | 2024-04-10T04:34:35Z |
| format | Article |
| id | doaj.art-00b1c86909234e0aaf29acb60e0c86e3 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-10T04:34:35Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-00b1c86909234e0aaf29acb60e0c86e32023-03-10T04:34:37ZengElsevierJournal of Functional Foods1756-46462023-03-01102105462Chia (Salvia hispanica L.) oil supplementation ameliorates liver oxidative stress in high-fat diet-fed mice through PPAR-γ and Nrf2 upregulationAline Batista0Fernanda Torres Quitete1Thamara Cherem Peixoto2André Almo3Elisa Bernardes Monteiro4Patrícia Trindade5Lilia Zago6Marta Citelli7Julio Beltrame Daleprane8Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, RJ 20550-900, BrazilDepartment of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, RJ 20550-900, BrazilDepartment of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, RJ 20550-900, BrazilDepartment of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, RJ 20550-900, BrazilDepartment of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, RJ 20550-900, BrazilDepartment of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, RJ 20550-900, BrazilDepartment of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, RJ 20550-900, BrazilDepartment of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, RJ 20550-900, BrazilCorresponding author at: Instituto de Nutrição, Rua São Francisco Xavier, 524, sala 12150 bloco F, 20550-900 Rio de Janeiro, RJ, Brazil.; Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, RJ 20550-900, BrazilThis study aimed to evaluate the hepatic antioxidant activity of a high-fat diet supplemented with chia oil in mice. Forty animals were divided into Control (C, n = 10), Control + 1.5 % chia oil (CC, n = 10), High fat (HF, n = 10), and High fat + 1.5 % chia oil (HFC, n = 10) groups. Chia oil reduced serum triacylglycerol in the HF group (p < 0.05). Chia oil promotes lower hepatic concentrations of F2-isoprostane (8-epi PGF2α) and thiobarbituric acid (TBARs) than HF. Chia oil increased liver protein expression and activity of superoxide dismutase 1 and 2 (SOD1 and SOD2), catalase (CAT), and glutathione peroxidase (GPx). It also upregulated the expression of PPAR-γ and NRF2, a master transcription factor involved in the antioxidant response in the liver, compared to their counterparts. The results reveal that chia oil improves the metabolic and antioxidant systems in the liver of high-fat diet-fed mice.http://www.sciencedirect.com/science/article/pii/S1756464623000622Oxidative stressChia oilAntioxidantHigh-fat dietNon-alcoholic fatty liver disease |
| spellingShingle | Aline Batista Fernanda Torres Quitete Thamara Cherem Peixoto André Almo Elisa Bernardes Monteiro Patrícia Trindade Lilia Zago Marta Citelli Julio Beltrame Daleprane Chia (Salvia hispanica L.) oil supplementation ameliorates liver oxidative stress in high-fat diet-fed mice through PPAR-γ and Nrf2 upregulation Journal of Functional Foods Oxidative stress Chia oil Antioxidant High-fat diet Non-alcoholic fatty liver disease |
| title | Chia (Salvia hispanica L.) oil supplementation ameliorates liver oxidative stress in high-fat diet-fed mice through PPAR-γ and Nrf2 upregulation |
| title_full | Chia (Salvia hispanica L.) oil supplementation ameliorates liver oxidative stress in high-fat diet-fed mice through PPAR-γ and Nrf2 upregulation |
| title_fullStr | Chia (Salvia hispanica L.) oil supplementation ameliorates liver oxidative stress in high-fat diet-fed mice through PPAR-γ and Nrf2 upregulation |
| title_full_unstemmed | Chia (Salvia hispanica L.) oil supplementation ameliorates liver oxidative stress in high-fat diet-fed mice through PPAR-γ and Nrf2 upregulation |
| title_short | Chia (Salvia hispanica L.) oil supplementation ameliorates liver oxidative stress in high-fat diet-fed mice through PPAR-γ and Nrf2 upregulation |
| title_sort | chia salvia hispanica l oil supplementation ameliorates liver oxidative stress in high fat diet fed mice through ppar γ and nrf2 upregulation |
| topic | Oxidative stress Chia oil Antioxidant High-fat diet Non-alcoholic fatty liver disease |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623000622 |
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