Optimization of the k2′ Parameter Estimation for the Pharmacokinetic Modeling of Dynamic PIB PET Scans Using SRTM2

Optimization of the k2′ Parameter Estimation for the Pharmacokinetic Modeling of Dynamic PIB PET Scans Using SRTM2

Background: This study explores different approaches to estimate the clearance rate of the reference tissue (k2′) parameter used for pharmacokinetic modeling, using the simplified reference tissue model 2 (SRMT2) and further explores the effect on the binding potential (BPND) of 11C-labeled Pittsbur...

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Bibliographic Details
Main Authors: Débora E. Peretti, Fransje E. Reesink, Janine Doorduin, Bauke M. de Jong, Peter P. De Deyn, Rudi A. J. O. Dierckx, Ronald Boellaard, David Vállez García
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Physics
Subjects:
Alzheimer's disease
pharmacokinetic modeling
Pittsburgh compound B
SRTM
SRTM2
Online Access:https://www.frontiersin.org/article/10.3389/fphy.2019.00212/full

Internet

https://www.frontiersin.org/article/10.3389/fphy.2019.00212/full

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