Preliminary Investigation of the Antibacterial Activity of Antitumor Drug 3-Amino-1,2,4-Benzotriazine-1,4-Dioxide (Tirapazamine) and its Derivatives

Preliminary Investigation of the Antibacterial Activity of Antitumor Drug 3-Amino-1,2,4-Benzotriazine-1,4-Dioxide (Tirapazamine) and its Derivatives

The antitumor drug 3-amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ (<b>1</b>)) along with a number of newly synthesized tirapazamine derivatives (TPZs) bearing substitutions at the 3-amine position of TPZ (<b>1</b>) were estimated for their antibacterial activity a...

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Bibliographic Details
Main Authors: Evelina Polmickaitė-Smirnova, Jonas Šarlauskas, Kastis Krikštopaitis, Živilė Lukšienė, Zita Staniulytė, Žilvinas Anusevičius
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Applied Sciences
Subjects:
heterocyclic di-<i>N</i>-oxides
1,2,4-benzotriazine di-<i>N</i>-oxides
tirapazamine (TPZ)
antibacterial activity
minimum inhibitory concentrations (MICs)
chloramphenicol
Online Access:https://www.mdpi.com/2076-3417/10/12/4062

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https://www.mdpi.com/2076-3417/10/12/4062

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