Potential causal role of synovial complement system activation in the development of post-traumatic osteoarthritis after anterior cruciate ligament injury or meniscus tear

Potential causal role of synovial complement system activation in the development of post-traumatic osteoarthritis after anterior cruciate ligament injury or meniscus tear

Anterior cruciate ligament (ACL) injury and meniscal tear (MT) are major causal factors for developing post-traumatic osteoarthritis (PTOA), but the biological mechanism(s) are uncertain. After these structural damages, the synovium could be affected by complement activation that normally occurs in...

Full description

Bibliographic Details
Main Authors: V. Michael Holers, Rachel M. Frank, Andrew Clauw, Jennifer Seifert, Michael Zuscik, Sakthi Asokan, Christopher Striebich, Michael R. Clay, Larry W. Moreland, Nirmal K. Banda
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
complement system
anterior cruciate ligament
medial meniscus tear
lateral meniscus tear
osteoarthiritis
synovium
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1146563/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1146563/full

Similar Items