Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells

Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells

Sophisticated mechanisms that preserve genome integrity are critical to ensure the maintenance of regenerative capacity while preventing transformation of somatic stem cells (SCs), yet little is known about mechanisms regulating genome maintenance in these cells. Here, we show that intestinal stem c...

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Bibliographic Details
Main Authors: Pedro Sousa-Victor, Arshad Ayyaz, Rippei Hayashi, Yanyan Qi, David T. Madden, Victoria V. Lunyak, Heinrich Jasper
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
stem cell aging
chromatin stability
transposable elements
epigenetics
intestinal stem cell function
aging transcriptome
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311841

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http://www.sciencedirect.com/science/article/pii/S2211124717311841

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