Nuclear GSK-3β and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN

Nuclear GSK-3β and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN

Glycogen synthase kinase-3β (GSK-3β) is a downstream target of oncogenic KRas and can accumulate in the nucleus in pancreatic ductal adenocarcinoma (PDA). To determine the interplay between oncogenic KRas and nuclear GSK-3β in PDA development, we generated Lox-STOP-Lox (LSL) nuclear-targeted GSK-3β...

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Bibliographic Details
Main Authors: Li Ding, Kaely Roeck, Cheng Zhang, Brooke Zidek, Esther Rodman, Yasmin Hernandez-Barco, Jin-San Zhang, William Bamlet, Ann Oberg, Lizhi Zhang, Nabeel Bardeesy, Hu Li, Daniel Billadeau
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
GSK-3β
KRAS
AQP5
progenitor cell
intraductal papillary mucinous neoplasm
pancreatic adenocarcinoma
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.853003/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.853003/full

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