Binding interactions of epididymal protease inhibitor and semenogelin-1: a homology modeling, docking and molecular dynamics simulation study

Epididymal protease inhibitor (EPPIN) that is located on the sperm surface and specific to the male reproductive system is a non-hormonal contraceptive target, since the binding of EPPIN with the seminal plasma protein semenogelin-1 (SEMG1) causes a loss of sperm function. Here, we investigated the...

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Bibliographic Details
Main Authors: Changyu Shan, Hongwei Li, Yuping Zhang, Yuyan Li, Yingchun Chen, Wei He
Format: Article
Language:English
Published: PeerJ Inc. 2019-08-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/7329.pdf