Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation

Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation

Abstract Human sideroflexin 2 (SFXN2) belongs to the SFXN protein family, which is a mitochondrial outer membrane protein involved in mitochondrial iron metabolism. Mitochondria are indispensable for cellular energy production and iron metabolism. However, it remains elusive how SFXN2 modulates mito...

Full description

Bibliographic Details
Main Authors: Ying Chen, Jinjun Qian, Pinggang Ding, Wang Wang, Xinying Li, Xiaozhu Tang, Chao Tang, Ye Yang, Chunyan Gu
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05272-z

Internet

https://doi.org/10.1038/s41419-022-05272-z

Similar Items