Structure-function relationship of new peptides activating human Nav1.1

Structure-function relationship of new peptides activating human Nav1.1

Nav1.1 is an important pharmacological target as this voltage-gated sodium channel is involved in neurological and cardiac syndromes. Channel activators are actively sought to try to compensate for haploinsufficiency in several of these pathologies. Herein we used a natural source of new peptide com...

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Bibliographic Details
Main Authors: Ludivine Lopez, Stephan De Waard, Hervé Meudal, Cécile Caumes, Kuldip Khakh, Steve Peigneur, Barbara Oliveira-Mendes, Sophia Lin, Jolien De Waele, Jérôme Montnach, Sandrine Cestèle, Agnès Tessier, J.P. Johnson, Massimo Mantegazza, Jan Tytgat, Charles Cohen, Rémy Béroud, Frank Bosmans, Céline Landon, Michel De Waard
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Drug discovery
JzTx-34
Pharmacology
hNav1.1 channel
Biophysics
High-throughput screening
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223009642

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http://www.sciencedirect.com/science/article/pii/S0753332223009642

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