Animal-Free Human Whole Blood Sepsis Model to Study Changes in Innate Immunity

Animal-Free Human Whole Blood Sepsis Model to Study Changes in Innate Immunity

Studying innate immunity in humans is crucial for understanding its role in the pathophysiology of systemic inflammation, particularly in the complex setting of sepsis. Therefore, we standardized a step-by-step process from the venipuncture to the transfer in a human model system, while closely moni...

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Bibliographic Details
Main Authors: David Alexander Christian Messerer, Laura Vidoni, Maike Erber, Alexander Elias Paul Stratmann, Jonas Martin Bauer, Christian Karl Braun, Stefan Hug, Anna Adler, Kristina Nilsson Ekdahl, Bo Nilsson, Eberhard Barth, Peter Radermacher, Markus Huber-Lang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
inflammation
neutrophil granulocytes
lipopolysaccharide (LPS)
blood physiology
sepsis
ex vivo whole blood model
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.571992/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.571992/full

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