DNMT3a-mediated methylation of PSTPIP2 enhances inflammation in alcohol-induced liver injury via regulating STAT1 and NF-κB pathway

DNMT3a-mediated methylation of PSTPIP2 enhances inflammation in alcohol-induced liver injury via regulating STAT1 and NF-κB pathway

Alcohol-induced liver injury (ALI) is associated with inflammatory responses regulated by macrophages. Activation of macrophages plays a crucial role in ALI while DNA methylation-regulated gene silencing is associated with inflammation processes in macrophages. Proline-Serine-Threonine Phosphatase I...

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Bibliographic Details
Main Authors: Jie-Jie Xu, Lin Zhu, Hai-Di Li, Xiao-Sa Du, Juan-Juan Li, Na-Na Yin, Xiao-Ming Meng, Cheng Huang, Jun Li
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Pharmacological Research
Subjects:
Alcohol-induced liver injury (ALI)
Proline-serine-threonine-phosphatase-interacting protein 2 (PSTPIP2)
Inflammation
STAT1
DNA methylation
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822000706

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http://www.sciencedirect.com/science/article/pii/S1043661822000706

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