Pirfenidone ameliorates pulmonary arterial pressure and neointimal remodeling in experimental pulmonary arterial hypertension by suppressing NLRP3 inflammasome activation

Pirfenidone ameliorates pulmonary arterial pressure and neointimal remodeling in experimental pulmonary arterial hypertension by suppressing NLRP3 inflammasome activation

Abstract Pulmonary arterial hypertension (PAH) is a fatal disease characterized by increased pulmonary arterial pressure, inflammation, and neointimal remodeling of pulmonary arterioles. Serum levels of interleukin (IL)‐1β and IL‐18 are elevated in PAH patients and may enhance proinflammatory neoint...

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Bibliographic Details
Main Authors: Emmanouil Mavrogiannis, Quint A. J. Hagdorn, Venetia Bazioti, Johannes M. Douwes, Diederik E. Van Der Feen, Silke U. Oberdorf‐Maass, Marit Westerterp, Rolf M. F. Berger
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Pulmonary Circulation
Subjects:
caspase‐1
IL‐18
IL‐1β
vascular remodeling
Online Access:https://doi.org/10.1002/pul2.12101

Internet

https://doi.org/10.1002/pul2.12101

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