Autoantibodies Targeting AT<sub>1</sub>- and ET<sub>A</sub>-Receptors Link Endothelial Proliferation and Coagulation via Ets-1 Transcription Factor

Autoantibodies Targeting AT<sub>1</sub>- and ET<sub>A</sub>-Receptors Link Endothelial Proliferation and Coagulation via Ets-1 Transcription Factor

Scleroderma renal crisis (SRC) is an acute life-threatening manifestation of systemic sclerosis (SSc) caused by obliterative vasculopathy and thrombotic microangiopathy. Evidence suggests a pathogenic role of immunoglobulin G (IgG) targeting G-protein coupled receptors (GPCR). We therefore dissected...

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Bibliographic Details
Main Authors: Rusan Catar, Melanie Herse-Naether, Nan Zhu, Philine Wagner, Oskar Wischnewski, Angelika Kusch, Julian Kamhieh-Milz, Andreas Eisenreich, Ursula Rauch, Björn Hegner, Harald Heidecke, Angela Kill, Gabriela Riemekasten, Gunnar Kleinau, Patrick Scheerer, Duska Dragun, Aurelie Philippe
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
angiotensin
renin–angiotensin system
endothelin-1
systemic sclerosis
renal crisis
autoantibodies
Online Access:https://www.mdpi.com/1422-0067/23/1/244

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https://www.mdpi.com/1422-0067/23/1/244

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