Notch ankyrin domain: evolutionary rise of a thermodynamic sensor

Abstract Notch signalling pathway plays a key role in metazoan biology by contributing to resolution of binary decisions in the life cycle of cells during development. Outcomes such as proliferation/differentiation dichotomy are resolved by transcriptional remodelling that follows a switch from Notc...

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Bibliographic Details
Main Authors: Filip Vujovic, Neil Hunter, Ramin M. Farahani
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Cell Communication and Signaling
Subjects:
Online Access:https://doi.org/10.1186/s12964-022-00886-4