The Us2 Gene Product of Herpes Simplex Virus 2 modulates NF-κB activation by targeting TAK1

Abstract HSV-2 is one of the most common sexually transmitted pathogens worldwide and HSV-2 infection triggers cytokine and chemokine production. However, little is known about which HSV-2 genes engage in the regulation of NF-κB signaling and what mechanisms are involved. In a screen of the unique s...

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Bibliographic Details
Main Authors: Xuan Lu, Changjing Huang, Yi Zhang, Yong Lin, Xueyu Wang, Qian Li, Shi Liu, Jingfeng Tang, Li Zhou
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08856-4