Betulinic and ursolic acids from Nauclea latifolia roots mediate their antimalarial activities through docking with PfEMP-1 and PfPKG proteins

Betulinic and ursolic acids from Nauclea latifolia roots mediate their antimalarial activities through docking with PfEMP-1 and PfPKG proteins

Abstract Background Chemotherapies target the PfEMP-1 and PfPKG proteins in Plasmodium falciparum, the parasite that causes malaria, in an effort to prevent the disease’s high fatality rate. This work identified the phytochemical components of Nauclea latifolia roots and docked the chemical compound...

Full description

Bibliographic Details
Main Authors: Edet Effiong Asanga, Ndifreke Daniel Ekpo, Affiong Asuquo Edeke, Chinedum Martins Ekeleme, Henshaw Uchechi Okoroiwu, Uwem Okon Edet, Ekementeabasi A. Umoh, Nikita Elkanah Umoaffia, Olorunfemi Abraham Eseyin, Ani Nkang, Monday Akpanabiatu, Jude Efiom Okokon, Sylvia Akpotuzor, Bright Asuquo Effiong, MacGeorge Ettaba
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Nauclea latifolia
Malaria
Betulinic acid
Ursolic acid
Plasmodium berghei
Docking
Online Access:https://doi.org/10.1186/s12906-023-04324-x

Internet

https://doi.org/10.1186/s12906-023-04324-x

Similar Items