NPM1 alternative transcripts are upregulated in acute myeloid and lymphoblastic leukemia and their expression level affects patient outcome

NPM1 alternative transcripts are upregulated in acute myeloid and lymphoblastic leukemia and their expression level affects patient outcome

Abstract Background Expression of the NPM1 gene, encoding nucleophosmin, is upregulated in cancers. Although more than ten NPM1 transcripts are known, the reports were usually limited to one predominant transcript. In leukemia, the NPM1 expression has not been widely studied so far. In acute myeloid...

Full description

Bibliographic Details
Main Authors: Luiza Handschuh, Pawel Wojciechowski, Maciej Kazmierczak, Malgorzata Marcinkowska-Swojak, Magdalena Luczak, Krzysztof Lewandowski, Mieczyslaw Komarnicki, Jacek Blazewicz, Marek Figlerowicz, Piotr Kozlowski
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Translational Medicine
Subjects:
NPM1
Expression
AML
ALL
Splice variants
Quantitative transcript analysis
Online Access:http://link.springer.com/article/10.1186/s12967-018-1608-2

Internet

http://link.springer.com/article/10.1186/s12967-018-1608-2

Similar Items