Mechanism of DNA Intercalation by Chloroquine Provides Insights into Toxicity

Mechanism of DNA Intercalation by Chloroquine Provides Insights into Toxicity

Chloroquine has been used as a potent antimalarial, anticancer drug, and prophylactic. While chloroquine is known to interact with DNA, the details of DNA–ligand interactions have remained unclear. Here we characterize chloroquine–double-stranded DNA binding with four complementary approaches, inclu...

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Bibliographic Details
Main Authors: Joha Joshi, Micah J. McCauley, Michael Morse, Michael R. Muccio, Joseph G. Kanlong, Márcio S. Rocha, Ioulia Rouzina, Karin Musier-Forsyth, Mark C. Williams
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
chloroquine
intercalation
DNA binding
single molecule
optical tweezers
AFM
Online Access:https://www.mdpi.com/1422-0067/25/3/1410

Internet

https://www.mdpi.com/1422-0067/25/3/1410

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