Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic form of regulated cell death that has been implicated in maladaptive renal repair in mice and humans. Using single-cell transcriptomic and mouse genetic approaches, we show that proximal tubular (PT) cells de...

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Bibliographic Details
Main Authors: Shintaro Ide, Yoshihiko Kobayashi, Kana Ide, Sarah A Strausser, Koki Abe, Savannah Herbek, Lori L O'Brien, Steven D Crowley, Laura Barisoni, Aleksandra Tata, Purushothama Rao Tata, Tomokazu Souma
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
single-cell RNA sequencing
ferroptosis
kidney injury
repair
Online Access:https://elifesciences.org/articles/68603

Internet

https://elifesciences.org/articles/68603

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