The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study

The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study

After chemotherapy for the treatment of metastatic bladder urothelial carcinoma (UC), most patients inevitably encounter drug resistance and resultant treatment failure. Deubiquitinating enzymes (DUBs) remove ubiquitin from target proteins and play a critical role in maintaining protein homeostasis....

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Kuan-Lin Kuo, Shing-Hwa Liu, Wei-Chou Lin, Po-Ming Chow, Yu-Wei Chang, Shao-Ping Yang, Chung-Sheng Shi, Chen-Hsun Hsu, Shih-Ming Liao, Hong-Chiang Chang, Kuo-How Huang
Format: Artikel
Sprache:English
Veröffentlicht: MDPI AG 2019-10-01
Schriftenreihe:Cells
Schlagworte:
urothelial carcinoma
pr-619
chemotherapy resistance
deubiquitination
bcl-2
apoptosis
Online Zugang:https://www.mdpi.com/2073-4409/8/10/1268

Online

https://www.mdpi.com/2073-4409/8/10/1268

Ähnliche Einträge