DPPA3 facilitates genome-wide DNA demethylation in mouse primordial germ cells

DPPA3 facilitates genome-wide DNA demethylation in mouse primordial germ cells

Abstract Background Genome-wide DNA demethylation occurs in mammalian primordial germ cells (PGCs) as part of the epigenetic reprogramming important for gametogenesis and resetting the epigenetic information for totipotency. Dppa3 (also known as Stella or Pgc7) is highly expressed in mouse PGCs and...

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Bibliographic Details
Main Authors: Keisuke Toriyama, Wan Kin Au Yeung, Azusa Inoue, Kazuki Kurimoto, Yukihiro Yabuta, Mitinori Saitou, Toshinobu Nakamura, Toru Nakano, Hiroyuki Sasaki
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Genomics
Subjects:
Stella
Dppa3
Prdm14
Tet1
Primordial germ cell
DNA demethylation
Online Access:https://doi.org/10.1186/s12864-024-10192-7

Internet

https://doi.org/10.1186/s12864-024-10192-7

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