Genetic background determines synaptic phenotypes in Arid1b-mutant mice

Genetic background determines synaptic phenotypes in Arid1b-mutant mice

ARID1B, a chromatin remodeler, is strongly implicated in autism spectrum disorders (ASD). Two previous studies on Arid1b-mutant mice with the same exon 5 deletion in different genetic backgrounds revealed distinct synaptic phenotypes underlying the behavioral abnormalities: The first paper reported...

Full description

Bibliographic Details
Main Authors: Hyosang Kim, Eunjoon Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Psychiatry
Subjects:
ARID1B mutation
genetic background
miniature excitatory postsynaptic currents
miniature inhibitory postsynaptic currents
synaptic phenotype
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1341348/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1341348/full

Similar Items