Survival of rats bearing advanced intracerebral F 98 tumors after glutathione depletion and microbeam radiation therapy: conclusions from a pilot project

Survival of rats bearing advanced intracerebral F 98 tumors after glutathione depletion and microbeam radiation therapy: conclusions from a pilot project

Abstract Background Resistance to radiotherapy is frequently encountered in patients with glioblastoma multiforme. It is caused at least partially by the high glutathione content in the tumour tissue. Therefore, the administration of the glutathione synthesis inhibitor Buthionine-SR-Sulfoximine (BSO...

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Bibliographic Details
Main Authors: E. Schültke, E. Bräuer-Krisch, H. Blattmann, H. Requardt, J. A. Laissue, G. Hildebrandt
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Radiation Oncology
Subjects:
Animal model
Malignant brain tumour
Microbeam radiation therapy
Radioenhancement
Synchrotron X-rays
Online Access:http://link.springer.com/article/10.1186/s13014-018-1038-6

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http://link.springer.com/article/10.1186/s13014-018-1038-6

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