Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction.

Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction.

Treatment of neuromuscular diseases is still an unsolved problem. Evidence over the last years strongly indicates the involvement of malformation and dysfunction of neuromuscular junctions in the development of such medical conditions. Stabilization of NMJs thus seems to be a promising approach to a...

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Bibliographic Details
Main Authors: Stefan Hettwer, Shuo Lin, Stefan Kucsera, Monika Haubitz, Filippo Oliveri, Ruggero G Fariello, Markus A Ruegg, Jan W Vrijbloed
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3919806?pdf=render

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http://europepmc.org/articles/PMC3919806?pdf=render

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