Paeoniflorin Attenuates Inflammatory Pain by Inhibiting Microglial Activation and Akt-NF-κB Signaling in the Central Nervous System

Paeoniflorin Attenuates Inflammatory Pain by Inhibiting Microglial Activation and Akt-NF-κB Signaling in the Central Nervous System

Background/Aims: Paeoniflorin (PF) is known to have anti-inflammatory and paregoric effects, but the mechanism underlying its analgesic effect remains unclear. The aim of this study was to clarify the effect of PF on Freund’s complete adjuvant (CFA)-induced inflammatory pain and explore the underlyi...

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Bibliographic Details
Main Authors: Bo Hu, Guangtao Xu, Xiaomin Zhang, Long Xu, Hong Zhou, Zhenyi Ma, Xiaohua Shen, Jia Zhu, Ruilin Shen
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Paeoniflorin
Freund’s complete adjuvant
Pain
Microglia
Akt
NF-κB
Online Access:https://www.karger.com/Article/FullText/490076

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https://www.karger.com/Article/FullText/490076

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