Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia

Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia

Abstract Background Exercise is postulated to be a promising non-pharmacological intervention for the improvement of neurodegenerative disease pathology. However, the mechanism of beneficial effects of exercise on the brain remains to be further explored. In this study, we investigated the effect of...

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Bibliographic Details
Main Authors: Hao Han, Yawei Zhao, Junda Du, Sushan Wang, Xuehan Yang, Weijie Li, Jiayi Song, Siwei Zhang, Ziyi Zhang, Yongfei Tan, Grant M. Hatch, Ming Zhang, Li Chen
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Immunity & Ageing
Subjects:
Exercise
Lactate
Lactylation
Microglia
Neuroinflammation
Alzheimers disease
Online Access:https://doi.org/10.1186/s12979-023-00390-4

Internet

https://doi.org/10.1186/s12979-023-00390-4

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