MicroRNA-124 Enhances T Cells Functions by Manipulating the Lactic Acid Metabolism of Tumor Cells

MicroRNA-124 Enhances T Cells Functions by Manipulating the Lactic Acid Metabolism of Tumor Cells

High production of lactic acid is a common feature of various tumors. Lactic acid is an immunosuppressive molecule with crucial roles in tumor cells' immune escape, which could largely be attributed to its negative effects on the T cells present in the tumor microenvironment (TME). Strategies...

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Bibliographic Details
Main Authors: Mohammad Khakpoor-Koosheh, Hosein Rostamian, Elham Masoumi, Leila Jafarzadeh, Keyvan Fallah-Mehrjardi, Mohammad Javad Tavassolifar, Farshid Noorbakhsh, Hamid Reza Mirzaei, jamshid Hadjati, Nima Rezaei
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2023-02-01
Series:Iranian Journal of Allergy, Asthma and Immunology
Subjects:
Lactic acid
Metabolism
MIRN124 microRNA, human
T-lymphocytes
Tumor microenvironment
Online Access:https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3419

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https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3419

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