Transcriptional consequences of trisomy 21 on neural induction

Transcriptional consequences of trisomy 21 on neural induction

IntroductionDown syndrome, caused by trisomy 21, is a complex developmental disorder associated with intellectual disability and reduced growth of multiple organs. Structural pathologies are present at birth, reflecting embryonic origins. A fundamental unanswered question is how an extra copy of hum...

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Bibliographic Details
Main Authors: José L. Martinez, Jennifer G. Piciw, Madeline Crockett, Isabella A. Sorci, Nikunj Makwana, Carissa L. Sirois, Yathindar Giffin-Rao, Anita Bhattacharyya
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Down syndrome
iPSC
neurodevelopment
RNAseq
neural induction
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1341141/full

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https://www.frontiersin.org/articles/10.3389/fncel.2024.1341141/full

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