CRISPR/Cas9 mediated FGFR2 down-regulation alleviatespremature closure of cranial suture in an Apert syndromemouse model
Apert syndrome (AS) is characterized by synostosis of coronal sutures, midfacial hypoplasia,abnormity of brain, syndactyly of hands and feet. Majority of AS is caused by gain-of-function mutation of fibro‐blast growth factor receptor 2 (FGFR2). To date, the treatment of AS is surgical correction for...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Lanzhou University Press
2021-06-01
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| Series: | 生物医学转化 |
| Subjects: | |
| Online Access: | http://swyxzh.ijournals.cn/swyxzh/article/html/20210210?st=article_issue |