Immune responses, therapeutic anti-tumor effects, and tolerability upon therapeutic HPV16/18 E6/E7 DNA vaccination via needle-free biojector

Immune responses, therapeutic anti-tumor effects, and tolerability upon therapeutic HPV16/18 E6/E7 DNA vaccination via needle-free biojector

ABSTRACT Intramuscular vaccination of mice with the naked pBI-11 DNA plasmid targeting E6 and E7 of HPV16 and HPV18 via a conventional syringe and needle generates human papillomavirus (HPV) antigen-specific CD8+ T cell-mediated immune responses and therapeutic effects against the TC-1 tumor model....

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Bibliographic Details
Main Authors: Shiwen Peng, Hsin-Fang Tu, Michelle Cheng, Ming-Hung Hu, Hua-Ling Tsai, Ya-Chea Tsai, Chelsea Koenig, Cory Brayton, Hao Wang, Yung-Nien Chang, Rebecca C. Arend, Kimberly Levinson, Richard B. S. Roden, T. C. Wu, Chien-Fu Hung
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
human papillomavirus
HPV16
HPV18
E6
E7
DNA vaccine
Online Access:https://journals.asm.org/doi/10.1128/mbio.02121-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02121-23

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