Age-Dependent Behavioral and Metabolic Assessment of AppNL−G−F/NL−G−F Knock-in (KI) Mice

Age-Dependent Behavioral and Metabolic Assessment of AppNL−G−F/NL−G−F Knock-in (KI) Mice

Mitochondria play a crucial role in Alzheimer's disease (AD) onset and progression. Traditional transgenic AD mouse models which were widely used in the past decades share a common limitation: The overexpression of APP and overproduction of amyloid-beta (Aβ) are accompanied by other APP peptide...

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Bibliographic Details
Main Authors: Shanshan Wang, Taiga Ichinomiya, Paul Savchenko, Swetha Devulapalli, Dongsheng Wang, Gianna Beltz, Takashi Saito, Takaomi C. Saido, Steve L. Wagner, Hemal H. Patel, Brian P. Head
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
APP
knock-in
mitochondria dysfunction
cognition deficit
fusion/fission dynamic
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.909989/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2022.909989/full

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