ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology

ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology

Sarcomas are a heterogeneous group of tumors in which the role of ERK5 is poorly studied. To clarify the role of this MAPK in sarcomatous pathology, we used a murine 3-methyl-cholanthrene (3MC)-induced sarcoma model. Our data show that 3MC induces pleomorphic sarcomas with muscle differentiation, sh...

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Bibliographic Details
Main Authors: Elena Arconada-Luque, Jaime Jiménez-Suarez, Raquel Pascual-Serra, Syong Hyun Nam-Cha, Teresa Moline, Francisco J. Cimas, Germán Fliquete, Marta Ortega-Muelas, Olga Roche, Diego M. Fernández-Aroca, Raúl Muñoz Velasco, Natalia García-Flores, Cristina Garnés-García, Adrián Sánchez-Fdez, Sofía Matilla-Almazán, Víctor J. Sánchez-Arévalo Lobo, Javier Hernández-Losa, Borja Belandia, Atanasio Pandiella, Azucena Esparís-Ogando, Santiago Ramón y Cajal, Luis del Peso, Ricardo Sánchez-Prieto, María José Ruiz-Hidalgo
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
ERK5
<i>MAPK7</i>
soft tissue sarcoma
leiomyosarcoma
rhabdomyosarcoma
KLF2
Online Access:https://www.mdpi.com/2072-6694/14/14/3509

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https://www.mdpi.com/2072-6694/14/14/3509

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