Combined Luteolin and Indole-3-Carbinol Synergistically Constrains ERα-Positive Breast Cancer by Dual Inhibiting Estrogen Receptor Alpha and Cyclin-Dependent Kinase 4/6 Pathway in Cultured Cells and Xenograft Mice

Combined Luteolin and Indole-3-Carbinol Synergistically Constrains ERα-Positive Breast Cancer by Dual Inhibiting Estrogen Receptor Alpha and Cyclin-Dependent Kinase 4/6 Pathway in Cultured Cells and Xenograft Mice

The high concentrations of individual phytochemicals in vitro studies cannot be physiologically achieved in humans. Our solution for this concentration gap between in vitro and human studies is to combine two or more phytochemicals. We screened 12 phytochemicals by pairwise combining two compounds a...

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Bibliographic Details
Main Authors: Xiaoyong Wang, Lijuan Zhang, Qi Dai, Hongzong Si, Longyun Zhang, Sakina E. Eltom, Hongwei Si
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
synergistic
breast cancer
luteolin
indole-3-carbinol
combination
estrogen receptor alpha
Online Access:https://www.mdpi.com/2072-6694/13/9/2116

Internet

https://www.mdpi.com/2072-6694/13/9/2116

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