β-Arrestin2 promotes docetaxel resistance of castration-resistant prostate cancer via promoting hnRNP A1-mediated PKM2 alternative splicing

β-Arrestin2 promotes docetaxel resistance of castration-resistant prostate cancer via promoting hnRNP A1-mediated PKM2 alternative splicing

Abstract Purpose To investigate the influence of β-arrestin2 on the docetaxel resistance in castration-resistant prostate cancer (CRPC) and elucidate the underlying molecular mechanisms. Methods PC3 and DU145 cells with stable β-arrestin2 overexpression and C4-2 cells with stable β-arrestin2 knockdo...

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Bibliographic Details
Main Authors: Yuhao Zhou, Fei Li, Bangyu Zou, Xiaofeng Zhou, Lianmin Luo, Sicheng Dong, Zhiqing He, Zhixiong Zhang, Liqiong Liao, Hongxing Liu, Chao Cai, Di Gu, Xiaolu Duan
Format: Article
Language:English
Published: Springer 2023-11-01
Series:Discover Oncology
Subjects:
β-Arrestin2
PKM2
hnRNP A1
Docetaxel resistance
CRPC
Online Access:https://doi.org/10.1007/s12672-023-00740-0

Internet

https://doi.org/10.1007/s12672-023-00740-0

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