Intrapulmonary administration of recombinant activated factor VII in pediatric, adolescent, and young adult oncology and hematopoietic cell transplant patients with pulmonary hemorrhage

Intrapulmonary administration of recombinant activated factor VII in pediatric, adolescent, and young adult oncology and hematopoietic cell transplant patients with pulmonary hemorrhage

IntroductionDiffuse alveolar hemorrhage (DAH) is a devastating disease process with 50-100% mortality in oncology and hematopoietic cell transplant (HCT) recipients. High concentrations of tissue factors have been demonstrated in the alveolar wall in acute respiratory distress syndrome and DAH, alon...

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Bibliographic Details
Main Authors: Caitlin Hurley, Jennifer McArthur, Jeffrey M. Gossett, Elizabeth A. Hall, Patricia J. Barker, Diego R. Hijano, Melissa R. Hines, Guolian Kang, Jason Rains, Saumini Srinivasan, Ali Suliman, Amr Qudeimat, Saad Ghafoor
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Oncology
Subjects:
pulmonary hemorrhage
diffuse alveolar hemorrhage (DAH)
hematopoietic cell transplant (HCT)
recombinant factor VIIa
pediatric oncologic emergencies
critical care
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1375697/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1375697/full

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