Deletions of <i>CDKN2A</i> and <i>MTAP</i> Detected by Copy-Number Variation Array Are Associated with Loss of p16 and MTAP Protein in Pleural Mesothelioma

Deletions of <i>CDKN2A</i> and <i>MTAP</i> Detected by Copy-Number Variation Array Are Associated with Loss of p16 and MTAP Protein in Pleural Mesothelioma

<i>CDKN2A</i> deletion is a common alteration in pleural mesothelioma (PM) and frequently associated with co-deletion of <i>MTAP</i>. Since the standard detection method for <i>CDKN2A</i> deletion and FISH analysis is relatively expensive, we here investigated the...

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Bibliographic Details
Main Authors: Bart Vrugt, Michaela B. Kirschner, Mayura Meerang, Kathrin Oehl, Ulrich Wagner, Alex Soltermann, Holger Moch, Isabelle Opitz, Peter J. Wild
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cancers
Subjects:
pleural mesothelioma
p16
MTAP
molecular pathology
diagnostics
immunohistochemistry
Online Access:https://www.mdpi.com/2072-6694/15/20/4978

Internet

https://www.mdpi.com/2072-6694/15/20/4978

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