Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism

Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism

Summary: Proteolytic cleavage is an important post-translational mechanism to increase protein variability and functionality. In cancer, this process can be deregulated to shut off tumor-suppressive functions. Here, we report that in glioblastoma (GBM), the tumor suppressor ZBTB18 is targeted for pr...

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Bibliographic Details
Main Authors: Anie P. Masilamani, Rana Schulzki, Shuai Yuan, Ira V. Haase, Eva Kling, Franziska Dewes, Geoffroy Andrieux, Melanie Börries, Oliver Schnell, Dieter H. Heiland, Oliver Schilling, Roberto Ferrarese, Maria S. Carro
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:iScience
Subjects:
Biochemistry
Molecular biology
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222008975

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http://www.sciencedirect.com/science/article/pii/S2589004222008975

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