Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice

Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice

<p>Abstract</p> <p>Background</p> <p>Alzheimer's disease is a complex neurodegenerative disorder characterized pathologically by a temporal and spatial progression of beta-amyloid (Aβ) deposition, neurofibrillary tangle formation, and synaptic degeneration. Inflamm...

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Bibliographic Details
Main Authors: LaFerla Frank M, Oddo Salvatore, Mastrangelo Michael A, Janelsins Michelle C, Federoff Howard J, Bowers William J
Format: Article
Language:English
Published: BMC 2005-10-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Alzheimer's disease
beta-amyloid
pro-inflammatory molecule
microglia
3xTg-AD
TNF-α
MCP-1
Online Access:http://www.jneuroinflammation.com/content/2/1/23

Internet

http://www.jneuroinflammation.com/content/2/1/23

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