Protein degradation and protein synthesis in long-term memory formation

Long-term memory (LTM) formation requires transient changes in the activity of intracellular signaling cascades that are thought to regulate new gene transcription and de novo protein synthesis in the brain. Consistent with this, protein synthesis inhibitors impair LTM for a variety of behavioral t...

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Bibliographic Details
Main Authors: Timothy J Jarome, Fred J Helmstetter
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00061/full