Dieckol Inhibits Autophagic Flux and Induces Apoptotic Cell Death in A375 Human Melanoma Cells via Lysosomal Dysfunction and Mitochondrial Membrane Impairment

Dieckol Inhibits Autophagic Flux and Induces Apoptotic Cell Death in A375 Human Melanoma Cells via Lysosomal Dysfunction and Mitochondrial Membrane Impairment

Dieckol is a natural brown algal-derived polyphenol and its cytotoxic potential against various types of cancer cells has been studied. However, the effects of dieckol on autophagy in cancer cells remain unknown. Here, we show that dieckol inhibits the growth of A375 human melanoma cells by inducing...

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Bibliographic Details
Main Authors: Min-Hee Jo, Yong-Tae Kim, Sun Joo Park
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
dieckol
autophagy
apoptosis
cell death
melanoma
antitumor activity
Online Access:https://www.mdpi.com/1422-0067/23/22/14149

Internet

https://www.mdpi.com/1422-0067/23/22/14149

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