Multicharged Phthalocyanines as Selective Ligands for G-Quadruplex DNA Structures

Multicharged Phthalocyanines as Selective Ligands for G-Quadruplex DNA Structures

The stabilization of G-Quadruplex DNA structures by ligands is a promising strategy for telomerase inhibition in cancer therapy since this enzyme is responsible for the unlimited proliferation of cancer cells. To assess the potential of a compound as a telomerase inhibitor, selectivity for quadruple...

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Bibliographic Details
Main Authors: Catarina I. V. Ramos, Susana P. Almeida, Leandro M. O. Lourenço, Patrícia M. R. Pereira, Rosa Fernandes, M. Amparo F. Faustino, João P. C. Tomé, Josué Carvalho, Carla Cruz, M. Graça P. M. S. Neves
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
multicharged phthalocyanines
G-Quadruplexes
telomerase inhibition
selectivity
salmon sperm DNA
UV-Vis
hyperchromism
G4-FID
circular dichroism
Online Access:https://www.mdpi.com/1420-3049/24/4/733

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https://www.mdpi.com/1420-3049/24/4/733

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