Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil

ABSTRACT BACKGROUND: Red blood cell genes are highly polymorphic with the distribution of alleles varying between different populations and ethnic groups. The objective of this study was to investigate gene polymorphisms of blood groups in the state of Santa Catarina, Southern Brazil. METHODS: Th...

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Main Authors: Daiane Cobianchi Costa, Alessandra Arruda Schinaider, Thais Mattos Santos, Everaldo José Schörner, Daniel Simon, Sharbel Weidner Maluf, Ana Carolina Rabello de Moraes, Maria Claudia Silva Silva
Format: Article
Language:English
Published: Elsevier
Series:Revista Brasileira de Hematologia e Hemoterapia
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842016000300199&lng=en&tlng=en
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author Daiane Cobianchi Costa
Alessandra Arruda Schinaider
Thais Mattos Santos
Everaldo José Schörner
Daniel Simon
Sharbel Weidner Maluf
Ana Carolina Rabello de Moraes
Maria Claudia Silva Silva
author_facet Daiane Cobianchi Costa
Alessandra Arruda Schinaider
Thais Mattos Santos
Everaldo José Schörner
Daniel Simon
Sharbel Weidner Maluf
Ana Carolina Rabello de Moraes
Maria Claudia Silva Silva
author_sort Daiane Cobianchi Costa
collection DOAJ
description ABSTRACT BACKGROUND: Red blood cell genes are highly polymorphic with the distribution of alleles varying between different populations and ethnic groups. The objective of this study was to investigate gene polymorphisms of blood groups in the state of Santa Catarina, Southern Brazil. METHODS: Three hundred and seventy-three unrelated blood donors and 31 transfusion-dependent patients were evaluated to investigate polymorphisms of the Rh, Kell, Duffy, Kidd, and Diego blood group systems in a population from the state of Santa Catarina. The subjects, from seven regions that comprise the blood-banking network of the state, were assessed between August 2011 and March 2014. The genotypes of the Rh, Kell, Duffy, Kidd, and Diego systems were determined using the restriction fragment length polymorphism-polymerase chain reaction and allele-specific polymerase chain reaction techniques. RESULTS: The genotype frequencies in this study were significantly different when populations from different regions of Santa Catarina were compared. Furthermore, there were also significant differences in the genetic frequencies compared to other Brazilian states. The genotype frequencies of the Kell and Kidd blood groups are similar to European populations from Naples, Italy and Zurich, Switzerland. CONCLUSION: This article reports for the first time the frequency of polymorphisms of blood group systems in blood donors from Santa Catarina, Southern Brazil.
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spelling doaj.art-01170fd367f544579f7baa6780b7107b2022-12-22T02:03:32ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1806-087038319920510.1016/j.bjhh.2016.04.005S1516-84842016000300199Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern BrazilDaiane Cobianchi CostaAlessandra Arruda SchinaiderThais Mattos SantosEveraldo José SchörnerDaniel SimonSharbel Weidner MalufAna Carolina Rabello de MoraesMaria Claudia Silva SilvaABSTRACT BACKGROUND: Red blood cell genes are highly polymorphic with the distribution of alleles varying between different populations and ethnic groups. The objective of this study was to investigate gene polymorphisms of blood groups in the state of Santa Catarina, Southern Brazil. METHODS: Three hundred and seventy-three unrelated blood donors and 31 transfusion-dependent patients were evaluated to investigate polymorphisms of the Rh, Kell, Duffy, Kidd, and Diego blood group systems in a population from the state of Santa Catarina. The subjects, from seven regions that comprise the blood-banking network of the state, were assessed between August 2011 and March 2014. The genotypes of the Rh, Kell, Duffy, Kidd, and Diego systems were determined using the restriction fragment length polymorphism-polymerase chain reaction and allele-specific polymerase chain reaction techniques. RESULTS: The genotype frequencies in this study were significantly different when populations from different regions of Santa Catarina were compared. Furthermore, there were also significant differences in the genetic frequencies compared to other Brazilian states. The genotype frequencies of the Kell and Kidd blood groups are similar to European populations from Naples, Italy and Zurich, Switzerland. CONCLUSION: This article reports for the first time the frequency of polymorphisms of blood group systems in blood donors from Santa Catarina, Southern Brazil.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842016000300199&lng=en&tlng=enGenotypeBlood groupBlood donors
spellingShingle Daiane Cobianchi Costa
Alessandra Arruda Schinaider
Thais Mattos Santos
Everaldo José Schörner
Daniel Simon
Sharbel Weidner Maluf
Ana Carolina Rabello de Moraes
Maria Claudia Silva Silva
Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil
Revista Brasileira de Hematologia e Hemoterapia
Genotype
Blood group
Blood donors
title Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil
title_full Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil
title_fullStr Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil
title_full_unstemmed Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil
title_short Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil
title_sort frequencies of polymorphisms of the rh kell kidd duffy and diego systems of santa catarina southern brazil
topic Genotype
Blood group
Blood donors
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842016000300199&lng=en&tlng=en
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