Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil
ABSTRACT BACKGROUND: Red blood cell genes are highly polymorphic with the distribution of alleles varying between different populations and ethnic groups. The objective of this study was to investigate gene polymorphisms of blood groups in the state of Santa Catarina, Southern Brazil. METHODS: Th...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
|
Series: | Revista Brasileira de Hematologia e Hemoterapia |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842016000300199&lng=en&tlng=en |
_version_ | 1818023264670187520 |
---|---|
author | Daiane Cobianchi Costa Alessandra Arruda Schinaider Thais Mattos Santos Everaldo José Schörner Daniel Simon Sharbel Weidner Maluf Ana Carolina Rabello de Moraes Maria Claudia Silva Silva |
author_facet | Daiane Cobianchi Costa Alessandra Arruda Schinaider Thais Mattos Santos Everaldo José Schörner Daniel Simon Sharbel Weidner Maluf Ana Carolina Rabello de Moraes Maria Claudia Silva Silva |
author_sort | Daiane Cobianchi Costa |
collection | DOAJ |
description | ABSTRACT BACKGROUND: Red blood cell genes are highly polymorphic with the distribution of alleles varying between different populations and ethnic groups. The objective of this study was to investigate gene polymorphisms of blood groups in the state of Santa Catarina, Southern Brazil. METHODS: Three hundred and seventy-three unrelated blood donors and 31 transfusion-dependent patients were evaluated to investigate polymorphisms of the Rh, Kell, Duffy, Kidd, and Diego blood group systems in a population from the state of Santa Catarina. The subjects, from seven regions that comprise the blood-banking network of the state, were assessed between August 2011 and March 2014. The genotypes of the Rh, Kell, Duffy, Kidd, and Diego systems were determined using the restriction fragment length polymorphism-polymerase chain reaction and allele-specific polymerase chain reaction techniques. RESULTS: The genotype frequencies in this study were significantly different when populations from different regions of Santa Catarina were compared. Furthermore, there were also significant differences in the genetic frequencies compared to other Brazilian states. The genotype frequencies of the Kell and Kidd blood groups are similar to European populations from Naples, Italy and Zurich, Switzerland. CONCLUSION: This article reports for the first time the frequency of polymorphisms of blood group systems in blood donors from Santa Catarina, Southern Brazil. |
first_indexed | 2024-12-10T03:41:34Z |
format | Article |
id | doaj.art-01170fd367f544579f7baa6780b7107b |
institution | Directory Open Access Journal |
issn | 1806-0870 |
language | English |
last_indexed | 2024-12-10T03:41:34Z |
publisher | Elsevier |
record_format | Article |
series | Revista Brasileira de Hematologia e Hemoterapia |
spelling | doaj.art-01170fd367f544579f7baa6780b7107b2022-12-22T02:03:32ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1806-087038319920510.1016/j.bjhh.2016.04.005S1516-84842016000300199Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern BrazilDaiane Cobianchi CostaAlessandra Arruda SchinaiderThais Mattos SantosEveraldo José SchörnerDaniel SimonSharbel Weidner MalufAna Carolina Rabello de MoraesMaria Claudia Silva SilvaABSTRACT BACKGROUND: Red blood cell genes are highly polymorphic with the distribution of alleles varying between different populations and ethnic groups. The objective of this study was to investigate gene polymorphisms of blood groups in the state of Santa Catarina, Southern Brazil. METHODS: Three hundred and seventy-three unrelated blood donors and 31 transfusion-dependent patients were evaluated to investigate polymorphisms of the Rh, Kell, Duffy, Kidd, and Diego blood group systems in a population from the state of Santa Catarina. The subjects, from seven regions that comprise the blood-banking network of the state, were assessed between August 2011 and March 2014. The genotypes of the Rh, Kell, Duffy, Kidd, and Diego systems were determined using the restriction fragment length polymorphism-polymerase chain reaction and allele-specific polymerase chain reaction techniques. RESULTS: The genotype frequencies in this study were significantly different when populations from different regions of Santa Catarina were compared. Furthermore, there were also significant differences in the genetic frequencies compared to other Brazilian states. The genotype frequencies of the Kell and Kidd blood groups are similar to European populations from Naples, Italy and Zurich, Switzerland. CONCLUSION: This article reports for the first time the frequency of polymorphisms of blood group systems in blood donors from Santa Catarina, Southern Brazil.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842016000300199&lng=en&tlng=enGenotypeBlood groupBlood donors |
spellingShingle | Daiane Cobianchi Costa Alessandra Arruda Schinaider Thais Mattos Santos Everaldo José Schörner Daniel Simon Sharbel Weidner Maluf Ana Carolina Rabello de Moraes Maria Claudia Silva Silva Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil Revista Brasileira de Hematologia e Hemoterapia Genotype Blood group Blood donors |
title | Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil |
title_full | Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil |
title_fullStr | Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil |
title_full_unstemmed | Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil |
title_short | Frequencies of polymorphisms of the Rh, Kell, Kidd, Duffy and Diego systems of Santa Catarina, Southern Brazil |
title_sort | frequencies of polymorphisms of the rh kell kidd duffy and diego systems of santa catarina southern brazil |
topic | Genotype Blood group Blood donors |
url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842016000300199&lng=en&tlng=en |
work_keys_str_mv | AT daianecobianchicosta frequenciesofpolymorphismsoftherhkellkiddduffyanddiegosystemsofsantacatarinasouthernbrazil AT alessandraarrudaschinaider frequenciesofpolymorphismsoftherhkellkiddduffyanddiegosystemsofsantacatarinasouthernbrazil AT thaismattossantos frequenciesofpolymorphismsoftherhkellkiddduffyanddiegosystemsofsantacatarinasouthernbrazil AT everaldojoseschorner frequenciesofpolymorphismsoftherhkellkiddduffyanddiegosystemsofsantacatarinasouthernbrazil AT danielsimon frequenciesofpolymorphismsoftherhkellkiddduffyanddiegosystemsofsantacatarinasouthernbrazil AT sharbelweidnermaluf frequenciesofpolymorphismsoftherhkellkiddduffyanddiegosystemsofsantacatarinasouthernbrazil AT anacarolinarabellodemoraes frequenciesofpolymorphismsoftherhkellkiddduffyanddiegosystemsofsantacatarinasouthernbrazil AT mariaclaudiasilvasilva frequenciesofpolymorphismsoftherhkellkiddduffyanddiegosystemsofsantacatarinasouthernbrazil |