Somatic Mutations Detected in Parkinson Disease Could Affect Genes With a Role in Synaptic and Neuronal Processes

Somatic Mutations Detected in Parkinson Disease Could Affect Genes With a Role in Synaptic and Neuronal Processes

The role of somatic mutations in complex diseases, including neurodevelopmental and neurodegenerative disorders, is becoming increasingly clear. However, to date, no study has shown their relation to Parkinson disease’s phenotype. To explore the relevance of embryonic somatic mutations in sporadic P...

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Bibliographic Details
Main Authors: Irene Lobon, Manuel Solís-Moruno, David Juan, Ashraf Muhaisen, Federico Abascal, Paula Esteller-Cucala, Raquel García-Pérez, Maria Josep Martí, Eduardo Tolosa, Jesús Ávila, Raheleh Rahbari, Tomas Marques-Bonet, Ferran Casals, Eduardo Soriano
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Aging
Subjects:
Parkinson disease
somatic mutations
brain mosaicism
neurodegenaration
somatic genome alteration
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2022.851039/full

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https://www.frontiersin.org/articles/10.3389/fragi.2022.851039/full

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